Skip to content

HPA Essentials 60 Tablets

This is a practitioner-only product. Please arrange a telephone consultation with our health care practitioners to ensure this product is suitable for you.

Metagenics HPA Essentials is for a healthy adrenal & neuroendocrine function. High dose vitamin B5 helps healthy neuroendocrine function in combination with vitamin C for adrenal health. It can assist metabolism and synthesis of some neurotransmitters. This is a core product in the Metagenics Stress Less Program and Energy Program.

Vegan and free from soy, nuts, seeds, lactose, and gluten.

  • Improves the adrenal gland rhythm. A researched trial of 52 people demonstrated a daily combination of vitamins B1 and B6, and 900 mg ascorbic acid, improved glucocorticoid function of the adrenal glands, and simultaneously normalised the rhythmic activity of the gland.
  • Vitamins B1 and B12 help protect from HPA dysfunction and regulate the cortisol clock. Vitamin B1 has been shown to reduce cortisol activity in times of stress, thereby protecting the body against excessive cortisol. Although mecobalamin, the active form of vitamin B12, doesn’t increase levels of cortisol in the blood, evidence suggests it helps shift the cortisol secretion peak, helping place the cortisol clock back on schedule.
  • B vitamins needed for neurotransmitter synthesis. Vitamin B6 is important due to its function as a coenzyme in the biosynthesis of neurotransmitters GABA, noradrenaline, dopamine and serotonin. Pyridoxal 5-phosphate, (P5P), is the biologically active form of B6. Vitamin B5 is involved in the synthesis of melatonin from serotonin due to its progression to Coenzyme A (CoA), which donates its acetyl group to serotonin to convert to melatonin, which has been shown to have a favourable effect on certain dysphoric mental states such as restlessness, anxiety and depression. Vitamin B5 deficiency is specifically related to decreased adrenal function and biotin deficiency has been shown to contribute to adrenal insufficiency.

Each tablet contains:


Calcium ascorbate dihydrate

545 mg

Equivalent Ascorbic acid (Vitamin C)

450 mg

Calcium pantothenate (Vitamin B5)

300 mg

Citrus bioflavonoids extract

50 mg

Thiamine hydrocholoride (Vitamin B1)

50 mg

Nicotinamide (Vitamin B3)

50 mg

Pyridoxal 5-phosphate monohydrate (Vitamin B6)

50 mg

Riboflavin sodium phosphate (Vitamin B2)

20 mg


500 µg

Levomefolate calcium

217 µg

Equivalent Levomefolic acid (5-Methyltetrahydrofolate)

200 µg

Mecobalamin (Co-methylcobalamin) (Vitamin B12)

200 µg

Free from animal products, corn, dairy protein, lactose, eggs, gluten, wheat, nuts, yeast, soy protein and starches. Free from artificial colours, flavours and preservatives.