TMG Trimethylglycine

Allergy Research Group TMG Trimethylglycine provides 750mg trimethylglycine (TMG, betaine) per capsule to support methylation pathways, homocysteine metabolism and liver function. Acts as a cellular osmolyte, whose function is to protect proteins, enzymes and DNA structure in kidney and liver cells under stress.

Trimethylglycine (TMG) supports methylation, liver health, and homocysteine metabolism while acting as a cellular osmolyte for stress resilience. TMG assists homocysteine to be metabolized into methionine, resulting in the production of DMG (dimethylglycine). The two major functions of TMG in humans are as an osmolyte to protect cells under stress and as a methyl-group donor.

Offers dual-action support for methylation and cellular osmoprotection, making it uniquely valuable for stressprone tissues like the liver and kidney.

Ideal for individuals seeking to support cardiovascular and liver health, methylation balance, or homocysteine support, especially those with genetic polymorphisms affecting folate metabolism.

How it works?

Trimethylglycine (TMG): provides methyl groups to convert homocysteine to methionine via the enzyme betaine homocysteine methyltransferase (BHMT), especially active in the liver and kidneys. Bypasses MTHFR limitations: offering an alternative methylation route for individuals with the 677TT polymorphism or functional folate needs. Supports healthy homocysteine metabolism.
 Effective at lower doses with benefits observed at lower dietary intake levels of betaine.Acts as a cellular osmolyte protecting proteins, enzymes, and DNA while improving cellular fluid retention and resilience to osmotic stress which is particularly supportive for kidney cells.

As a dietary supplement, take 1 capsule twice daily before meals, or as directed by a healthcare practitioner.